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KMID : 0386319780110010091
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Korean Leprosy Bulletin
1978 Volume.11 No. 1 p.91 ~ p.100
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Therapeutic Effect of Rifampicin for the Lepromatous Type Patients
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Abstract
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In this study, seventy-nine lepromatous type leprosy patients who had been registered
at the World Vision Leprosy Research and Treatment Center were treated with
rifampicin and DDS. The therapeutic effects after taking rifampicin were compared with
those after taking DDS by means comparing the respective patients bacteriological
evaluations. The bacteriological evaluation was based on a comparison of the change of
the Bacterial Index(BI) and Solid Fragmented and Granularity (SFG) value of the
lepromatous type patients in the each group.
1. Three out of eight patients treated with rifampicin alone and 7 out of 15 patients
treated with rifampicin and DDS together because B.I. negative thirty-six months
treatment.
2. In the each group, the decrease in average B.I. of the patients who were treated with
rifampicin only was 2.7, while the decrease on average B.I. of the patients treated with
a combination of rifampicin and DDS was 2.0 and that of the patients treated with DDS
only was 1.4 after taking drugs for thirty six months. With this the decrease in average
8.1. of the group treated with rifampicin was more pronounced than that of the group
treated with DDS.
3. The duration of bacteriological negative conversion was shorter in the group, whose
B.1. at the begining of rifampicin treatment was low.
4. Bacteriological improvement was observed after treated with rifampicin 150mg∼
450mg/d for 36 months.
From the above results, it is concluded that rifampicin has greater and faster
therapeutic effects in the control of lepromatous type patients than DDS.
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